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A Look Inside a Brain on Magic Mushrooms

Does a brain on magic mushrooms look the same as one having a dream? That’s the conclusion of a study of 15 volunteers published this week in the journal Human Brain Mapping.

Researchers at Imperial College in London gave psilocybin, the psychedelic chemical in magic mushrooms, to the volunteers and then measured their brain activity using a functional magnetic resonance imaging (fMRI) brain scanner. Scientists at Goethe University in Germany participated in the analysis.

They found that activity in the hippocampus and anterior cingulate cortex, areas linked to emotional thinking, became more pronounced and appeared to be working together in a manner similar to the brain of a person dreaming. Dr. Robin Carhart-Harris, a leading expert in psychedelic research at Imperial College, was not surprised at the similarity.

People often describe taking psilocybin as producing a dreamlike state and our findings have, for the first time, provided a physical representation for the experience in the brain.

Brain scans from the psilocybin study.

Brain scans from the psilocybin study.

The scans also found disjointed and uncoordinated activity in the brain network linked to high-level thinking and self-consciousness. This could be linked to the mind expansion, emotional insight and creative thinking experienced by psilocybin users, says Dr. Carhart-Harris.

There may be something in the loosening of the mind that occurs both in dreaming and in the psychedelic state that could be useful in terms of facilitating creative insight. There’s a fluidity and fluency to cognition. Only now are we forming ideas about what that might rest on in terms of changes in brain activity.

The study also found that the regions of the brain that show reduced activity under psilocybin are the same areas that are overactive in depression. The researchers plan further tests to determine if mushrooms can be used as an alternative treatment for depression.

As always, it’s important to remember that these studies were conducted on healthy users in a controlled environment. However, it’s exciting that the potential of mushrooms continues to be confirmed with scientific research.

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Paul Seaburn Paul Seaburn is one of the most prolific writers at Mysterious Universe. He’s written for TV shows such as “The Tonight Show”, “Politically Incorrect” and an award-winning children’s program. He’s been published in “The New York Times” and “Huffington Post” and has co-authored numerous collections of trivia, puzzles and humor. Paul likes to add a bit of humor to each MU post he crafts. After all, the mysterious doesn’t always have to be serious.

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